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Mediators of Ca2(+)-dependent secretion.

A Chaudhry1, R P Rubin

  • 1Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond 23298.

Environmental Health Perspectives
|March 1, 1990
PubMed
Summary
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Calcium (Ca2+) and other messengers like diacylglycerol (DAG) and cyclic AMP (cAMP) modulate cell secretion. These pathways interact to control Ca2+-dependent secretion in nonexcitable cells.

Area of Science:

  • Cellular Biology
  • Signal Transduction
  • Biochemistry

Background:

  • Calcium (Ca2+) is essential for cellular secretion.
  • Other second messengers, including diacylglycerol (DAG) and cyclic AMP (cAMP), modulate Ca2+-dependent secretion.
  • These messengers amplify or inhibit secretory responses in nonexcitable cells.

Purpose of the Study:

  • To review the roles of DAG, arachidonic acid, and cAMP in modulating Ca2+-dependent secretion.
  • To explore the interplay between Ca2+ and other signaling pathways in nonexcitable cells.

Main Methods:

  • Review of existing literature on second messenger roles in secretion.
  • Analysis of experimental findings on Ca2+ and signaling pathways in various cell types (e.g., exocrine pancreas, parotid gland, neutrophils).

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Main Results:

  • Diacylglycerol (DAG) and Ca2+ act synergistically to stimulate secretion, indicating a need for both pathways.
  • Arachidonic acid can act as both a positive and negative regulator of secretion, depending on the cell type.
  • Norepinephrine-stimulated secretion in the parotid gland requires the interaction of Ca2+ and cAMP pathways.

Conclusions:

  • Phosphoinositide and cAMP-dependent pathways play coordinated roles in signal transduction.
  • These pathways ultimately lead to Ca2+-mediated secretion in nonexcitable cells.
  • Understanding these interactions is crucial for comprehending secretory processes.