Related Experiment Video

Updated: Jun 1, 2026

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell (MSC) Spheroids Primed in 3-D Cultures Under Xeno-free Conditions
11:05

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell (MSC) Spheroids Primed in 3-D Cultures Under Xeno-free Conditions

Published on: March 18, 2017

Mesenchymal stromal cell 'licensing': a multistep process

M Krampera1

  • 1Stem Cell Research Laboratory, Department of Medicine, Section of Hematology, University of Verona, Verona, Italy. mauro.krampera@univr.it

Leukemia
|May 28, 2011
PubMed

Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenvironment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects.

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