Related Experiment Video

Updated: Jun 1, 2026

Cell Subtype-specific Analysis of Neuronal Membrane Proteasome in Somatosensory Neurons
09:27

Cell Subtype-specific Analysis of Neuronal Membrane Proteasome in Somatosensory Neurons

Published on: October 10, 2025

Trabectedin-related rhabdomyolysis: an uncommon but fatal toxicity

Aikaterini Stoyianni1, Nikolaos Kapodistrias, Eleutherios Kampletsas

  • 1Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece.

Tumori
|May 28, 2011
PubMed

Insights

Trabectedin can cause rhabdomyolysis, a serious muscle condition. This case study details a patient with uterine leiomyosarcoma who recovered fully from drug-induced rhabdomyolysis.

Area of Science:

  • Oncology
  • Pharmacology
  • Nephrology

Background:

  • Rhabdomyolysis is a critical condition involving muscle breakdown and potential kidney failure.
  • Trabectedin is an established chemotherapy agent used for soft tissue sarcomas.
  • Uterine leiomyosarcoma is a rare malignancy requiring effective treatment options.

Observation:

  • A patient with recurrent metastatic uterine leiomyosarcoma developed rhabdomyolysis.
  • The patient received Trabectedin as part of her treatment regimen.
  • The rhabdomyolysis resolved completely following medical intervention.

Findings:

  • This case highlights Trabectedin as a potential iatrogenic cause of rhabdomyolysis.
  • A review of existing literature was conducted to identify patterns of Trabectedin-induced rhabdomyolysis.
  • Early recognition and management are crucial for favorable outcomes.

Implications:

  • Clinicians should maintain a high index of suspicion for rhabdomyolysis in patients treated with Trabectedin.
  • Understanding the emergence patterns may aid in predicting and preventing this adverse event.
  • This case contributes to the understanding of Trabectedin's safety profile in gynecologic oncology.

Related Concept Videos

Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.