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Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

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Related Experiment Video

Updated: Jun 1, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
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The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Genetic testing in renal disease.

Detlef Bockenhauer1, Alan J Medlar, Emma Ashton

  • 1Institute of Child Health, University College London, London, UK. Detlef.Bockenhauer@nhs.net

Pediatric Nephrology (Berlin, Germany)
|May 28, 2011
PubMed
Summary
This summary is machine-generated.

Genomic sequencing technology has rapidly advanced, making whole genome sequencing faster and cheaper. This revolution in genetics promises to transform medicine, but requires careful consideration of its benefits and risks.

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Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

Area of Science:

  • Genomics
  • Medical Genetics
  • Bioinformatics

Background:

  • The first human genome sequencing in 2003 was a 13-year, $2.7 billion international effort.
  • Current genomic technologies enable whole genome sequencing in weeks for under $10,000.
  • The $1,000 genome is nearing reality, signaling a new era in genetic analysis.

Purpose of the Study:

  • To review the advancements in genomic sequencing technologies.
  • To differentiate the practical applications from the hype surrounding these technologies.
  • To address the implications of rapid genomic advancements for medical practice.

Main Methods:

  • Review of current high-throughput sequencing technologies.
  • Analysis of cost-effectiveness and time efficiency of new genomic platforms.
  • Discussion of the clinical utility and ethical considerations of widespread genomic data.

Main Results:

  • Significant reduction in genome sequencing time and cost.
  • Emergence of accessible and rapid genomic data for clinical use.
  • Identification of key areas for physician education regarding genomic medicine.

Conclusions:

  • Rapid advancements in genomic sequencing are poised to revolutionize medical practice.
  • Understanding the capabilities and limitations of new technologies is crucial for physicians.
  • Informed application of genomic technologies will enhance patient care and outcomes.