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Updated: Jun 1, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Rates of early intervention referral and significant developmental delay, by birthweight and gestational age
Allison E Curry1, Melissa R Pfeiffer, Meredith E Slopen
1Center for Injury Research and Prevention, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 1150, Philadelphia, PA 19104, USA. currya@email.chop.edu
Insights
Birthweight and gestational age independently impact child development. Combining these factors refines eligibility for Early Intervention services, identifying high-risk infants for developmental delay and ensuring timely support.
Area of Science:
- Pediatrics
- Developmental Psychology
- Public Health
Background:
- Birthweight (BW) and gestational age (GA) are independently associated with cognitive and neurological outcomes.
- Current Early Intervention (EI) service eligibility criteria vary, potentially excluding high-risk infants.
- Understanding BW-GA combinations is crucial for identifying at-risk populations.
Purpose of the Study:
- To evaluate the relationship between BW-GA combinations and EI referral rates.
- To assess the risk of EI-diagnosed developmental delay based on BW-GA categories.
- To inform eligibility criteria for EI services.
Main Methods:
- Linked NYC birth certificates (1999-2001) of surviving infants to EI administrative data (n=339,522).
- Calculated EI referral rates across various BW-GA categories.
- Employed logistic modeling to estimate predicted risk of developmental delay.
Main Results:
- EI referral rates exceeded 50% for infants born <1,250 g and those born <30 weeks with BW 1,250-1,499 g.
- Over half of infants in these categories were predicted to have developmental delays.
- Infants born >2,500 g and 39+ weeks had a <10% predicted risk of delay.
Conclusions:
- A BW threshold of <1,250 g identifies the highest-risk infants.
- Incorporating GA (<30 weeks) as an additional criterion prevents overlooking high-risk infants with higher birthweights.
- Physicians and EI programs should utilize BW-GA data to guide referrals and eligibility for developmental support.
Abstract:
Though correlated, birthweight (BW) and gestational age (GA) have independent effects on cognitive and neurological outcomes. Jurisdictions vary in their inclusion of these two characteristics in their list of established conditions for automatic eligibility for Early Intervention (EI) services, which may lead them to miss important high-risk groups. We evaluated the relationship between BW-GA combinations and both EI referral rates and risk of EI-diagnosed significant developmental delay in a population of New York City (NYC) births. We linked birth certificates of children born in NYC to resident mothers during 1999-2001 and surviving the first 28 days of life (n = 339,522) to EI administrative data. We calculated EI referral rates for various BW-GA categories, and used a logistic model to directly estimate the predicted risk of delay. EI referral rates of over 50% were observed in children born <1,250 g and those born <30 weeks and 1,250-1,499 g. Additionally, more than one in two children born either less than 1,250 g or <30 weeks and 1,250-1,499 g were predicted to be diagnosed with a developmental delay, compared with almost one-tenth among those born >2,500 g and 39+ weeks. A BW threshold of <1,250 g would identify children with the highest risk of delay; GA as an additional criterion would prevent overlooking high-risk children born <30 weeks but at higher birthweights. Physicians should monitor children with high-risk birth characteristics and refer them, if appropriate, for formal evaluation. EI programs may use these findings to guide determination of automatic eligibility criteria.
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