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Gastrulation

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Related Experiment Video

Updated: Jun 1, 2026

Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations

Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations

Published on: February 12, 2010

Imaging pluripotent cell migration in Drosophila.

Michael J Murray¹, Robert Saint

¹Molecular Genetics and Evolution, Research School of Biological Sciences, Australian National University, Acton, ACT, Australia.

Methods in Molecular Biology (Clifton, N.J.)

|May 28, 2011

Summary

Fruit fly embryos provide a model for studying cell migration. Researchers review methods for visualizing pluripotent embryonic cell movements, including advanced photoactivatable fluorescent protein techniques.

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Last Updated: Jun 1, 2026

Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations

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Published on: February 12, 2010

Live Imaging of Glial Cell Migration in the Drosophila Eye Imaginal Disc

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Imaging of Cell Shape Alteration and Cell Movement in Drosophila Gastrulation Using DE-cadherin Reporter Transgenic Flies

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Published on: December 29, 2016

Area of Science:

Developmental Biology
Cell Biology
Genetics

Background:

Drosophila melanogaster is a model organism for studying cell migration.
Embryonic development involves cell migration, including mesodermal, endodermal, and germ cell movements.
Traditional visualization methods include fixed embryo staining and live imaging.

Purpose of the Study:

To review previous studies on pluripotent embryonic cell migration in Drosophila.
To detail methods for visualizing cell migration during embryonic development.

Main Methods:

Utilizing photoactivatable fluorescent proteins for cell labeling.
Fusing fluorescent proteins to subcellular components to visualize cellular aspects during migration.
Live imaging and traditional staining techniques.

Main Results:

Photoactivatable fluorescent proteins enable tracking of small cell groups or single cells.
Visualizing subcellular components provides insights into migratory mechanisms.
Review synthesizes current knowledge and methods.

Conclusions:

Drosophila offers a robust system for cell migration analysis.
Advanced imaging techniques enhance the study of cell migration dynamics.
Detailed methods facilitate future research in developmental cell migration.