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Updated: Jun 1, 2026

Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach
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Association between sociability and diffusion tensor imaging in BALB/cJ mice.

Sungheon Kim1, Stephen Pickup, Andrew H Fairless

  • 1Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Sungheon.Kim@nyumc.org

NMR in Biomedicine
|May 28, 2011
PubMed
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High-resolution diffusion tensor imaging (DTI) revealed brain regions linked to sociability in mice. Specific DTI metrics correlated with social sniffing behavior, offering insights into the neurobiology of social interaction.

Area of Science:

  • Neuroscience
  • Biomedical Imaging
  • Behavioral Science

Background:

  • Sociability is a complex behavior influenced by neural circuits.
  • Diffusion Tensor Imaging (DTI) is a powerful tool for non-invasively assessing white matter microstructure.
  • Understanding the neural basis of sociability is crucial for various neurological and psychiatric conditions.

Purpose of the Study:

  • To investigate the association between DTI metrics and sociability in BALB/c inbred mice.
  • To identify specific brain regions and their microstructural properties related to social behavior.
  • To demonstrate the feasibility of using DTI for studying the neurobiology of sociability.

Main Methods:

  • High-resolution ex vivo DTI data acquired from 12 BALB/cJ mouse brains using a 9.4-T vertical-bore magnet.

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Last Updated: Jun 1, 2026

Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach
08:24

Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach

Published on: May 15, 2016

Assessment of Social Interaction Behaviors
06:41

Assessment of Social Interaction Behaviors

Published on: February 25, 2011

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

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  • Sociability operationalized as time spent sniffing a stimulus mouse in a social choice test for prepubescent mice.
  • Regression analysis employed to correlate DTI metrics (fractional anisotropy, mean diffusivity) with social sniffing time.

    • Main Results:

    • Significant positive regression between social sniffing time and fractional anisotropy found in 10 brain regions, including thalamic nuclei, zona incerta/substantia nigra, and cortical areas.
    • Significant negative regression between social sniffing time and mean diffusivity identified in five brain regions, including sensory/motor cortex and amygdala.
    • Tertiary eigenvalue negatively correlated with social sniffing time in all regions showing significant regression with mean diffusivity or fractional anisotropy.

    Conclusions:

    • DTI can detect brain regions associated with sociability in a mouse model.
    • Specific white matter microstructural differences in regions like the thalamus and cortex are linked to variations in social behavior.
    • This study validates DTI as a feasible method for exploring the neural underpinnings of social interaction.