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Adenosine blocks calcium entry in activated neutrophils and binds to flunarizine-sensitive calcium channels
F L Pasini1, P L Capecchi, A L Pasqui
1Institute of Medical Pathology, University of Siena, Policlinico, Le Scotte, Italy.
Immunopharmacology and Immunotoxicology
|January 1, 1990
Abstract:
Adenosine is able to prevent Ca+(+) influx into activated neutrophils as detected by the specific fluorescent indicator Quin 2. Such an effect is shown in a similar fashion by the calcium entry blocker flunarizine. The binding interaction between flunarizine and the neutrophil membrane as well as the flunarizine-adenosine antagonism are shown by the 1H-NMR technique, thus supporting evidence of a competition between the agents at the same or a nearby site on the cell membrane.