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Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

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Strategy for pulsed ionization methods on a sector mass spectrometer.

J D Lennon¹, D Shinn, R W Vachet

¹Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, and Department of Chemistry, Auburn University, Auburn, Alabama 30597.

Analytical Chemistry

|May 31, 2011

Summary

A novel method enhances pulsed ionization on double-focusing sector mass spectrometers using an inductive detector. This allows rapid, complete time-of-flight mass spectra acquisition, improving efficiency and simultaneous analysis.

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Area of Science:

Analytical Chemistry
Mass Spectrometry
Spectroscopy

Background:

Pulsed ionization methods are crucial for mass spectrometry.
Double-focusing sector mass spectrometers offer high resolution.
Previous methods required sequential data acquisition, limiting efficiency.

Purpose of the Study:

To develop an efficient method for pulsed ionization on double-focusing sector mass spectrometers.
To enable rapid and complete mass spectral acquisition.
To integrate time-of-flight analysis with sector mass analysis.

Main Methods:

Implementation of an inductive detector between electric and magnetic sectors.
Acquisition of time-of-flight mass spectra using single laser shots.
Simultaneous mass analysis using the sector instrument.

Main Results:

A crude, complete time-of-flight mass spectrum can be acquired with minimal laser shots.
Eliminates the need for sequentially compiling limited mass ranges.
Enables simultaneous time-of-flight and sector mass analysis.

Conclusions:

The described method significantly improves the efficiency of pulsed ionization on double-focusing sector mass spectrometers.
The inductive detector facilitates rapid and comprehensive mass spectral data acquisition.
This approach integrates two mass analysis techniques for enhanced analytical capabilities.