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Published on: December 15, 2011
Differences between pediatric and adult celiac disease
Luis Rodrigo-Sáez1, Dolores Fuentes-Álvarez, Isabel Pérez-Martínez
1Department of Digestive Diseases, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain. lrodrigosaez@gmail.com
Pediatric celiac disease (CD) presents with classic symptoms and higher serology rates, while adult CD shows atypical forms, delayed diagnosis, and more associated autoimmune conditions. Both groups have distinct clinical and diagnostic profiles.
Area of Science:
- Gastroenterology
- Immunology
- Pediatrics
Background:
- Celiac disease (CD) is a prevalent autoimmune disorder affecting 1-2% of the population.
- CD manifestation and diagnosis differ significantly between pediatric and adult populations.
Purpose of the Study:
- To compare clinical differences in celiac disease expression between children and adults.
- To analyze diagnostic findings in pediatric versus adult celiac disease patients.
Main Methods:
- Retrospective analysis of patients diagnosed with celiac disease.
- Comparison between a pediatric cohort (age < 14 years) and an adult cohort (age > 14 years).
Main Results:
- Classic CD forms predominated in children (79%) versus atypical forms in adults (86%).
- Adults experienced longer diagnostic delays (10 years vs. 1 year in children) and higher rates of associated autoimmune diseases (24.3% vs. 9.3%).
- Children showed higher rates of positive serology (TGt-2: 88% vs. 31%) and villous atrophy (95% vs. 33%) compared to adults.
Conclusions:
- Pediatric celiac disease is characterized by classic presentations, higher serological markers, and less diagnostic delay.
- Adult celiac disease frequently presents atypically, with increased diagnostic delay, milder histological findings, and a higher prevalence of associated autoimmune conditions.
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