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Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri
P Geck1, S A Whitaker, M M Medveczky
1Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.
Journal of Virology
|July 1, 1990
Abstract:
Sequencing demonstrates that the oncogenic regions of a group A strain and a group C strain of herpesvirus saimiri are nonhomologous. A bicistronic viral mRNA from this region is transcribed in tumor cells transformed by a highly oncogenic group C virus. The first open reading frame is homologous to collagen; no such sequences were found in group A or B strains. This is the first report that a virus encodes for sequences similar to those of a connective tissue protein.