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Structures of TGF-β receptor complexes: implications for function and therapeutic intervention using ligand traps

Andrew P Hinck1, Maureen D O'Connor-McCourt

  • 1Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. hinck@uthscsa.edu

Current Pharmaceutical Biotechnology
|May 31, 2011
PubMed
Summary

Transforming growth factor-beta (TGF-β) isoforms are crucial signaling molecules involved in cell growth and development. This review details their structures, receptor interactions, and potential for targeted therapies in diseases like fibrosis and cancer.

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