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[Relationship between MnSOD polymorphisms and susceptibility of chronic poisoning exposed to manganism

Shao-lei Cai1, Ming-xia Sun, Yong-jian Yan

  • 1Shandong Academy of Occupational Health and Occupational Medicine, Jinan 250062, China.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases
|May 31, 2011
PubMed
Abstract

Insights

Manganese Superoxide Dismutase (MnSOD) gene polymorphisms, specifically the 9Ala-Val variant, are linked to increased susceptibility to occupational manganism. Individuals with the VV genotype face a higher risk of developing chronic manganese poisoning.

Area of Science:

  • Environmental Health
  • Toxicology
  • Genetics

Context:

  • Occupational exposure to manganese can lead to manganism, a neurodegenerative disorder.
  • Genetic factors may influence an individual's susceptibility to manganese toxicity.

Purpose:

  • To investigate the association between Manganese Superoxide Dismutase (MnSOD) gene polymorphisms and the risk of developing chronic occupational manganism.
  • To determine if specific MnSOD genotypes increase susceptibility to manganese poisoning in occupationally exposed individuals.

Summary:

  • A case-control study analyzed MnSOD 9Ala-Val genotypes in 164 patients with occupational manganism and 328 controls using PCR-RFLP.
  • A significant difference in the MnSOD 9Ala-Val mutant allele frequency was observed between cases and controls (P < 0.01).
  • Individuals with the VV genotype exhibited a significantly increased risk (OR = 2.30) of occupational chronic manganism poisoning compared to AV or AA genotypes.

Impact:

  • MnSOD gene polymorphisms, particularly the VV genotype, may serve as a biomarker for increased susceptibility to chronic occupational manganism.
  • Findings suggest a genetic predisposition to manganese toxicity, informing targeted prevention strategies for high-risk workers.

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