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Related Experiment Video

Updated: Jun 1, 2026

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

Published on: September 13, 2018

Perioperative neuroprotection.

Klaus Ulrich Klein¹, Kristin Engelhard

¹Department of Anaesthesiology, University Medical Center of the Johannes Gutenberg-University, Langenbeckstr. 1, 55131 Mainz, Germany. kuklein@uni-mainz.de

Best Practice & Research. Clinical Anaesthesiology

|May 31, 2011

Summary

This summary is machine-generated.

Cerebral injuries harm the brain by limiting oxygen and glucose. While many neuroprotective agents show promise in animals, human trials often fail due to complex injury mechanisms and timing issues.

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Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

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Published on: June 2, 2015

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Last Updated: Jun 1, 2026

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

Published on: September 13, 2018

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Area of Science:

Neuroscience
Cerebral Physiology
Neuroprotection

Background:

Cerebral injuries, including stroke and trauma, result in inadequate oxygen and glucose supply, initiating neuronal death.
Numerous neuroprotective agents have been explored, yet few have proven effective in human clinical trials despite success in animal models.

Purpose of the Study:

To review essential physiological mechanisms for maintaining adequate brain oxygen and glucose supply.
To examine the influence of potential neuroprotective strategies and agents in the perioperative setting.

Main Methods:

Review of existing literature on cerebral physiology and homeostasis.
Analysis of neuroprotective strategies investigated for cerebral ischemia.
Focus on perioperative applications and clinical trial outcomes.

Main Results:

Failure of many pharmacological approaches in human trials suggests multiple injury mechanisms and critical timing.
Understanding cerebral physiology and homeostasis is crucial for effective neuroprotection.
Multiple mechanisms of injury likely necessitate multiple mechanisms of neuroprotection.

Conclusions:

Effective neuroprotection requires a deep understanding of brain physiology and the complex, multifactorial nature of ischemic injury.
Future strategies may need to target multiple pathways and consider precise timing for optimal outcomes in perioperative settings.