Thyroid status and kidney transplantation outcomes.

Area of Science:

• Nephrology
• Endocrinology
• Transplant Surgery

Background:

• End-stage renal disease (ESRD) patients often exhibit thyroid dysfunction.
• The relationship between thyroid function and renal transplant graft outcomes requires further clarification.

Purpose of the Study:

• To assess thyroid function in renal transplant recipients.
• To correlate thyroid hormone levels with graft function and clinical parameters.

Main Methods:

• Cross-sectional study of 136 renal transplant recipients.
• Evaluation of serum FT3, FT4, and TSH levels.
• Correlation analysis with BMI, eGFR, creatinine, proteinuria, electrolytes, lipids, and Hb.

Main Results:

• No significant correlation found between FT4/TSH and clinical variables.
• FT3 levels showed significant differences between sexes.
• FT3 correlated significantly with serum creatinine, eGFR, serum sodium, BMI, and Hb.

Conclusions:

• Low serum FT3 levels are associated with worse graft function, anemia, and altered BMI and sodium levels.
• Serum FT3 may serve as a predictive marker for kidney transplant graft function, particularly in the early post-transplant period (within 5 years).