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Updated: Jun 1, 2026

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Published on: July 21, 2023
Insertion/deletion polymorphism of the angiotensin-converting enzyme predicts left ventricular hypertrophy after
R Fedor1, L Asztalos, L Locsey
1University of Debrecen, Medical and Health Science Center, Division of Clinical Physiology, Debrecen, Hungary. f_roli@yahoo.com
Background:
Kidney transplant recipients show a higher risk for cardiovascular complications, such as left ventricular hypertrophy and heart failure, leading to the premature death in many cases.
Methods:
We investigated the contribution of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to the development of left ventricular hypertrophy (LVH), an indicator of heart disease progression among kidney transplant recipients.
Results:
We observed a significant correlation between graft function and left ventricular mass index. The occurrence of LVH or severe LVH was significantly greater among patients with at least one D-allele (ID or DD).
Conclusion:
The use of ACE inhibitors or angiotensin receptor blockers seemed to be advantageous for patients with the ID and especially, the DD genotype.
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