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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Bioavailability: Influencing Factors01:22

Bioavailability: Influencing Factors

Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Extended 78&#37; Hepatectomy in a Mouse Surgical Model
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Published on: May 24, 2024

Decrease in bone mass in women after liver transplantation: associated factors.

L F Baccaro1, I F S F Boin, A O Pedro

  • 1Department of Gynecology, State University of Campinas, Campinas, Brazil. luiz.baccaro@gmail.com

Transplantation Proceedings
|May 31, 2011
PubMed
Summary
This summary is machine-generated.

Postmenopausal women and those transplanted later in life face higher risks of decreased bone mass after liver transplantation. Early transplant duration may reduce this risk, highlighting the need for targeted osteoporosis management.

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Last Updated: Jun 1, 2026

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05:25

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Published on: May 24, 2024

Area of Science:

  • Hepatology
  • Transplantation Medicine
  • Bone Metabolism

Background:

  • Liver transplant recipients often experience osteoporosis, a common complication.
  • An increasing number of female recipients are reaching menopause, necessitating research into bone health.

Purpose of the Study:

  • To evaluate factors associated with decreased bone mass in women post-liver transplantation.
  • To identify at-risk populations for osteoporosis in this cohort.

Main Methods:

  • Prospective, cross-sectional study of 23 women ≥35 years old, ≥1 year post-liver transplant.
  • Assessed patient history, liver enzymes, and bone mineral density (lumbar spine, femur).
  • Statistical analysis included Fisher's exact test, odds ratios (OR), and Spearman's correlation.

Main Results:

  • 21% had osteoporosis, 35% had low bone mass.
  • Postmenopausal status (OR 69.0), age ≥49 (OR 13.33), and transplant age ≥44 (OR 49.50) were linked to lower bone mass.
  • Transplant duration >5.8 years decreased risk (OR 0.11); corticosteroid use was not associated.

Conclusions:

  • Osteoporosis is prevalent in female liver transplant recipients.
  • Menopause, older age, and later transplant age are key risk factors for decreased bone mass.
  • Understanding these factors is crucial for improving diagnosis and treatment strategies.