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Repetitive stimulation increases the activation rate of skeletal muscle Ca2+ currents
J Garcia1, A J Avila-Sakar, E Stefani
1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030.
Pflugers Archiv : European Journal of Physiology
|April 1, 1990
Abstract:
Voltage clamp experiments were conducted in frog skeletal muscle using repetitive stimulation protocols. The activation rate of Ca2+ currents increased by prepulses to depolarizing potentials or by stimulating the fiber with a frequency of 1.7 Hz at 0 mV. The effect was observable with Ca2+ or Ba2+ ions, and was clearly voltage-dependent. Physiologically, it is relevant that such activation rate increase can take place during a train of action potentials.