Differential conditioned fear response predicts duloxetine treatment outcome in male veterans with PTSD: a pilot study
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Deane E Aikins1, Eric D Jackson, Alicia Christensen
1Department of Psychiatry, Yale University, 300 George Street, New Haven, CT 06511, USA. deane.aikins@yale.edu
Psychiatry Research
|May 31, 2011
Abstract:
This pilot study tested whether posttraumatic stress disorder (PTSD) patients with impaired conditioned fear acquisition were refractory to open-label duloxetine treatment. Patients with a differential conditioned fear response at pre-treatment subsequently demonstrated significant reductions in PTSD symptoms. These data provide initial evidence of a putative biomarker of selective treatment response in PTSD.
