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Updated: Jun 1, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Discovery of novel xanthone derivatives as xanthine oxidase inhibitors
Lina Hu1, Honggang Hu, Weifeng Wu
1Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Abstract:
Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. In this study, a series of xanthone derivatives were synthesized as effective and a new class of xanthine oxidase inhibitor. Compounds 8a, 8c, 8i, 8g and 8r showed good inhibition against xanthine oxidase. The presence of a cyano group at the para position of benzyl moiety turned out to be the preferred substitution pattern. Molecular modeling studies were performed to gain an insight into its binding mode with xanthine oxidase, and to provide the basis for further structure-guided design of new non-purine xanthine oxidase inhibitors associated with the xanthone framework.
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