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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
Structure of delay in carotid surgery--an observational study
P Vikatmaa1, T Sairanen, J-M Lindholm
1Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland. pirkka.vikatmaa@hus.fi
This study looked at how long it took patients with carotid artery stenosis to receive surgery after experiencing symptoms. It found that the median time from symptom onset to surgery was 47 days, with only 11% of patients treated within the recommended two-week window. The longest delays occurred within the hospital system, mainly due to waiting for operating theatre availability. Emergency consultations with neurologists were associated with a higher likelihood of timely surgery. The study suggests that centralizing care at hospitals with surgical capacity and urgent investigation of stroke and transient ischemic attack patients could help reduce delays and improve stroke prevention.
Area of Science:
- Vascular surgery outcomes research within neurology
- Stroke prevention strategies in clinical medicine
Background:
Guidelines recommend prompt investigation and treatment for symptomatic carotid artery stenosis to prevent stroke. Prior research has shown that delays in diagnosis and surgery increase stroke risk. However, the extent of delays in real-world settings remains unclear. This gap motivated the study to evaluate referral pathways and time intervals in a specific hospital region. No prior work had resolved how often recommended timelines are met in practice. Stroke prevention is a critical area in neurology and vascular surgery. Existing data suggest variability in patient care timelines. This paper's contribution is to quantify delays and identify factors influencing them. The study focuses on a single hospital region to provide localized insights.
Purpose Of The Study:
The aim of this observational study was to assess the time delays from initial symptoms to carotid endarterectomy (CEA) in patients with symptomatic carotid artery stenosis. The specific problem addressed is the lack of data on real-world adherence to guideline-recommended timelines. The motivation stems from the need to improve stroke prevention through timely interventions. The study sought to identify factors contributing to delays in surgical treatment. It also aimed to determine if certain referral pathways reduced delays. The focus was on a single hospital region to ensure consistent data collection. The goal was to inform clinical practice and hospital resource allocation. The study highlights the importance of emergency consultations for timely care.
Main Methods:
The study used an observational design with a cohort of 100 consecutive patients scheduled for CEA at Helsinki University Central Hospital. Data collection involved analyzing medical records from August 2007 to September 2008. The primary outcome was the time interval from the index ischemic symptom to surgery. Secondary outcomes included delays within the hospital system. Patient records were reviewed to calculate median and range values. Statistical analysis included odds ratios to assess the impact of emergency consultations. The study focused on symptomatic patients only to ensure relevance. The methodology emphasized tracking referral pathways to identify bottlenecks.
Main Results:
The median time from symptom onset to surgery was 47 days, with a range of 3 to 688 days. The longest delay occurred within the hospital system, with a median of 25 days from consultation to surgery. Only 11% of patients underwent CEA within the recommended two-week window. Emergency consultations with neurologists increased the likelihood of timely surgery (OR 12.6, 95% CI 1.5-104). The main cause of in-hospital delay was waiting for operating theatre availability. Delays were generally too long to meet guideline recommendations. The study found significant variability in patient care timelines. Centralizing care at hospitals with surgical capacity is suggested to reduce delays.
Conclusions:
The findings suggest that delays from symptom onset to carotid surgery are often longer than recommended. The authors propose that emergency consultations improve adherence to guideline timelines. They suggest centralizing care at hospitals with surgical capacity to reduce delays. The study highlights the importance of prompt investigation and treatment. The authors note that in-hospital delays are primarily due to theatre availability. They suggest that all stroke and transient ischemic attack patients should be evaluated urgently. The study supports the need for improved coordination between specialties. The authors conclude that current referral pathways are suboptimal for timely stroke prevention.
Frequently Asked Questions
The median time from symptom onset to surgery was 47 days, with only 11% of patients operated within the recommended two weeks.
Emergency consultations increased the odds of surgery within two weeks (OR 12.6, 95% CI 1.5-104).
The main cause was waiting for operating theatre availability, with a median delay of 25 days.
Centralization is proposed to reduce delays and ensure prompt investigation and treatment of symptomatic patients.
Only 11% of patients underwent surgery within the recommended two weeks.
The authors suggest that all such patients should be evaluated on an emergency basis to prevent delays.
