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Related Concept Videos

Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

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Related Experiment Video

Updated: Jun 1, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Establishing and evaluating pediatric thyroid reference intervals on the Roche Modular Analytics E 170 using

M P A Henderson1, V Grey

  • 1Department of Pathology and Molecular Medicine, McMaster University Medical Centre, McMaster University, 1200 Main St W, Hamilton ON, Canada. matthew.henderson@medportal.ca

Clinical Biochemistry
|May 31, 2011
PubMed
Summary
This summary is machine-generated.

This study establishes age-specific reference intervals for free thyroxine and thyroid stimulating hormone in children. These population-based results are crucial for accurate clinical laboratory testing.

Related Experiment Videos

Last Updated: Jun 1, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Area of Science:

  • Clinical Chemistry
  • Pediatric Endocrinology
  • Laboratory Medicine

Background:

  • Accurate thyroid function testing in children requires age-specific reference intervals.
  • Existing manufacturer intervals may not accurately reflect pediatric populations.
  • Establishing precise reference ranges is vital for diagnosing thyroid disorders in pediatrics.

Purpose of the Study:

  • To determine age-specific reference intervals for free thyroxine (FT4) and thyroid stimulating hormone (TSH) in a pediatric cohort.
  • To compare these population-based intervals with manufacturer-provided reference ranges.
  • To enhance the accuracy of thyroid function assessments in pediatric patients.

Main Methods:

  • Data partitioning into age groups and outlier removal using the Tukey method.
  • Application of the Harris and Boyd algorithm for group merging.
  • Calculation of reference intervals using non-parametric and robust methods with bootstrapping for confidence intervals.

Main Results:

  • Provides non-parametric and robust reference intervals for FT4 and TSH.
  • Includes 90% confidence intervals for the upper and lower limits of these reference ranges.
  • Results are specific to measurements obtained using the Roche Modular Analytics E 170 platform.

Conclusions:

  • Highlights the critical need for population-based reference intervals in clinical laboratories.
  • Emphasizes that established intervals improve diagnostic accuracy for pediatric thyroid function.
  • Supports the routine implementation of tailored reference ranges for pediatric testing.