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Ex vivo decrease in uranium diffusion through intact and excoriated pig ear skin by a calixarene nanoemulsion.

Aurélie Spagnul1, Céline Bouvier-Capely, Guillaume Phan

  • 1Faculté de Pharmacie, Châtenay-Malabry, France.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
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A novel calixarene nanoemulsion effectively traps uranium on skin, significantly reducing systemic absorption. This breakthrough offers a promising emergency treatment for cutaneous uranium contamination.

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Area of Science:

  • Nuclear chemistry
  • Materials science
  • Dermatology

Background:

  • Cutaneous contamination by radionuclides, particularly uranium, poses significant risks in the nuclear industry.
  • Current emergency treatments for uranium skin exposure are insufficient for effective actinide removal.
  • Development of targeted treatments is crucial to mitigate uranium's systemic transfer from skin.

Purpose of the Study:

  • To develop and evaluate a novel nanoemulsion formulation for treating cutaneous uranium contamination.
  • To assess the efficacy of the calixarene nanoemulsion in trapping uranium and preventing its percutaneous absorption.
  • To investigate the impact of prompt and delayed application on uranium diffusion kinetics and skin distribution.

Main Methods:

  • Development of a nanoemulsion incorporating calixarene molecules with uranium-chelating properties.
  • Assessment of uranium percutaneous diffusion using Franz cells with intact and excoriated pig ear skin biopsies over 24 hours.
  • Analysis of uranium distribution within skin layers using Secondary Ion Mass Spectrometry (SIMS) microscopy.

Main Results:

  • Prompt application of the calixarene nanoemulsion reduced uranium diffusion by 94% through intact skin and 98% through excoriated skin.
  • Delayed application (up to 30 minutes) still showed significant efficacy, reducing 24-hour uranium transfer through excoriated skin by 71%.
  • No significant accumulation of uranium or uranium-calixarene chelates was observed in the skin layers.

Conclusions:

  • The developed calixarene nanoemulsion demonstrates high efficiency in trapping uranium on the skin.
  • The formulation effectively limits the percutaneous transfer of uranium into the bloodstream.
  • This nanoemulsion represents a promising therapeutic option for managing cutaneous uranium contamination.