Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Antidepressant Drugs: Overview

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Toward a biopsychosocial tipping point framework: insights from sexual medicine.

Sexual medicine reviews·2026

Same author

Letter to the Editor.

Journal of sex & marital therapy·2025

Same author

Comment on "Similarities and differences between men with self-reported lifelong and acquired difficulty reaching orgasm."

International journal of impotence research·2025

Same author

How has the biopsychosocial model fared in sexual medicine and sex therapy?

Sexual medicine reviews·2025

Same author

Correction: Comment on "The post-finasteride syndrome: possible etiological mechanisms and symptoms".

International journal of impotence research·2024

Same author

Comment on "The post-finasteride syndrome: possible etiological mechanisms and symptoms".

International journal of impotence research·2024

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Erectile dysfunction and depression: screening and treatment.

Michael A Perelman¹

¹Human Sexuality Program, Payne Whitney Clinic, The New York Presbyterian Hospital, New York, NY, USA. perelman@earthlink.net

The Urologic Clinics of North America

|May 31, 2011

Summary

Men with high depression scores are nearly twice as likely to experience erectile dysfunction (ED). This review explores the link between ED and depression, treatment effects, and screening strategies for this common comorbidity.

Related Experiment Videos

Last Updated: Jun 1, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

Men's Health
Psychiatry
Urology

Background:

Erectile dysfunction (ED) and depression frequently coexist in men.
Depression is a significant predictor of ED, independent of other factors.
Understanding this comorbidity is crucial for effective patient care.

Purpose of the Study:

To review the current knowledge on the relationship between ED and depression.
To examine the impact of depression treatments on ED.
To discuss improved screening and treatment strategies for comorbid ED and depression.

Main Methods:

Literature review of studies on ED and depression.
Analysis of epidemiological and clinical data.
Synthesis of current research findings.

Main Results:

Men with higher depression scores are almost twice as likely to report ED.
Depression is a common comorbidity in both community and clinical ED samples.
Evidence suggests a strong bidirectional relationship between ED and depression.

Conclusions:

Effective screening for depression in men with ED is essential.
Treatment of depression may improve ED symptoms.
Integrated treatment approaches are needed for men with comorbid ED and depression.