Related Experiment Video

Updated: Jun 1, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Home intravenous antimicrobial therapy in multi-drug resistant microorganism infections]

Jordi Pérez-López1, José Pardos-Gea, Antonio San José Laporte

  • 1Unidad de Hospitalización a Domicilio, Servicio de Medicina Interna, Hospital General Universitario Vall d'Hebron, Barcelona, España. jordpere@vhebron.net

Medicina Clinica
|May 31, 2011
PubMed
Abstract

Insights

Home intravenous antimicrobial infusion therapy (HIVAIT) is effective for multi-drug resistant infections. Careful patient selection is key for successful treatment outcomes and reduced hospital readmissions.

Area of Science:

  • Infectious Diseases
  • Hospital at Home Care
  • Antimicrobial Stewardship

Context:

  • Home intravenous antimicrobial infusion therapy (HIVAIT) is established for common infections.
  • Limited data exists on HIVAIT for multi-drug resistant (MDR) microorganism infections.
  • Hospital at Home Units (HHU) provide an alternative care setting.

Purpose:

  • To evaluate the clinical and epidemiological characteristics of patients with MDR infections receiving HIVAIT.
  • To assess the utility and outcomes of HIVAIT in patients with MDR infections.
  • To compare outcomes between MDR infection patients and a control group receiving HIVAIT.

Summary:

  • A study of 487 patients (82 with MDR infections) treated with HIVAIT in an HHU from 2007-2010.
  • MDR infection patients exhibited higher comorbidity and physical dependence.
  • While most patients showed clinical improvement, MDR patients had higher rates of hospital readmission during and after treatment.

Impact:

  • HIVAIT demonstrates utility in treating MDR infections when patients are appropriately selected.
  • Findings highlight the need for careful patient selection in HIVAIT for complex infections.
  • Results inform clinical practice regarding the use of HIVAIT for challenging microbial pathogens.

More Related Videos

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

Related Concept Videos

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...