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Change of mean platelet volume values in asthmatic children as an inflammatory marker

T Tuncel1, P Uysal, A B Hocaoglu

  • 1Dokuz Eylul University Hospital, Department of Pediatrics, Division of Allergy, Balcova, Izmir, Turkey. tuba.tuncel@deu.edu.tr

Allergologia Et Immunopathologia
|May 31, 2011
PubMed

Insights

Mean platelet volume (MPV) is not a reliable indicator for diagnosing or monitoring asthma. This study found no significant difference in MPV levels between asthmatic children and healthy controls, or between asthmatic patients during asymptomatic periods and exacerbations.

Area of Science:

  • Pediatric Allergy and Immunology
  • Hematology
  • Respiratory Medicine

Background:

  • Childhood asthma is a prevalent chronic respiratory disease.
  • T helper-2 cells, mast cells, and eosinophils are key inflammatory players in asthma.
  • Platelets, and specifically mean platelet volume (MPV) as a marker of platelet activation, are increasingly recognized for their potential role in asthma.

Purpose of the Study:

  • To investigate and compare mean platelet volume (MPV) levels in children with asthma.
  • To assess MPV during both asymptomatic periods and exacerbations of asthma.
  • To compare MPV in asthmatic children against age- and sex-matched healthy controls.

Main Methods:

  • A retrospective study involving 100 asthmatic children (mean age 8.2±3.3 years) and 49 healthy children.
  • Comparison of MPV values between asthmatic patients (during asymptomatic and exacerbation phases) and the control group.
  • Analysis of MPV variations in relation to atopy, infection, eosinophilia, IgE levels, and asthma severity.

Main Results:

  • No statistically significant difference was observed in MPV values between asthmatic patients and healthy controls (p>0.05).
  • MPV levels did not differ significantly between asthmatic patients during asymptomatic periods and during exacerbations (p>0.05).
  • Factors such as atopy, infection, eosinophilia, elevated immunoglobulin E, and asthma severity did not influence MPV values.

Conclusions:

  • Mean platelet volume (MPV) does not appear to be a useful biomarker for bronchial asthma in children.
  • Further prospective studies with larger cohorts are warranted to definitively ascertain the role of MPV in asthma.
  • Current findings suggest MPV is not a reliable indicator for asthma diagnosis or monitoring.
Abstract

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