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A mouse attenuated mutant of Junin virus with an altered envelope glycoprotein
L A Scolaro1, S E Mersich, E B Damonte
1Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Archives of Virology
|January 1, 1990
Abstract:
The XJC13 strain of Junin virus (JV) and the mouse-attenuated mutant C167 showed different GP38 peptide mapping after limited proteolysis with ficin and papain; viral infectivity of both viruses also exhibited a different susceptibility to protease treatment. A correlation between envelope glycoprotein alteration and JV virulence in neonatal mice is proposed.