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Updated: Jun 1, 2026

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization
Published on: April 7, 2023
A family with Xq22.3q25 interstitial deletion and normal ovarian function
Long-Ching Kuan1, Mei-Tsz Su, Chin-Ming Wu
1Department of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan.
Objective:
To investigate genomic changes in a family with deletion of X chromosome q22.3-q25 associated with normal constitutional and reproductive phenotypes.
Design:
Case report.
Setting:
Academic district hospital genetic laboratory.
Patient(S):
A family incidentally found to have deletion of X chromosome q22.3-q25.
Intervention(S):
Cytogenetic analysis and array-based comparative genomic hybridization for amniotic fluid and peripheral blood lymphocyte of family members.
Main Outcome Measure(S):
Ovarian function and menstrual cycles.
Result(S):
The proband and two daughters showed deletion of Xq22.3q25. This region spans 17.4 Mb and contains 121 genes.
Conclusion(S):
Female subjects with deletion of Xq22.3q25 may present with normal constitutional and reproductive phenotypes.
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