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Related Experiment Video

Updated: Jun 1, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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Inhaled corticosteroid dosing: double for nothing?

H William Kelly¹

¹Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131-0001, USA. hwkelly@salud.unm.edu

The Journal of Allergy and Clinical Immunology

|May 31, 2011

Summary

This summary is machine-generated.

Doubling inhaled corticosteroid (ICS) doses offers minimal benefit in asthma trials. Higher, four-fold increases show greater improvement, suggesting a need to re-evaluate ICS dosing as a trial control.

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Area of Science:

Pulmonology
Clinical Trials
Pharmacology

Background:

Recent National Heart, Lung, and Blood Institute trials question the use of doubled inhaled corticosteroid (ICS) doses.
ICS are commonly used in asthma management and clinical trials.

Purpose of the Study:

To evaluate the efficacy of doubling ICS doses as a positive control in asthma add-on therapy trials.
To review existing literature on ICS dose-response relationships.

Main Methods:

Literature review of studies assessing ICS dose-response.
Analysis of data from National Heart, Lung, and Blood Institute asthma clinical trials.

Main Results:

Most studies show no significant benefit from doubling ICS doses.
Four-fold ICS dose increases demonstrate efficacy comparable to or exceeding add-on long-acting bronchodilators.

Conclusions:

Doubling ICS doses should not be considered a standard positive control in asthma trials.
While not ideal for trials, doubled ICS doses may benefit individual patients.