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Updated: Jun 1, 2026
Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Assessment of tumor response to tyrosine kinase inhibitors
1Department of Radiation Oncology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Abstract:
This review briefly summarizes recent developments in the use of non-invasive imaging to assess tumor response to TKI therapy. Receptor tyrosine kinases play important roles in cancer development. A new class of drugs, tyrosine kinase inhibitors (TKI) can induce rapid and dramatic tumor suppression when administered to carefully selected patient groups. Identifying these patients with responding tumors prior to or shortly after the initiation of therapy remains challenging. The gold standard of response assessment has been by invasive biopsies used in biological and biochemical procedures. Advances in non-invasive imaging at the anatomical, functional and molecular level have enabled the early detection of tumor response; sometimes within days of beginning treatment. The growing area of molecular imaging has spurred the discovery of novel targeting peptides to bind TKI responding tumors. The emergence of targeted, quick responding imaging probes advances the field of cancer management towards the goal of personalized medicine.
Insights
Non-invasive imaging rapidly assesses tumor response to tyrosine kinase inhibitors (TKI) therapy. Molecular imaging and novel probes enable early detection, advancing personalized cancer medicine.
Area of Science:
- Oncology
- Radiology
- Molecular Imaging
Background:
- Receptor tyrosine kinases are crucial in cancer development.
- Tyrosine kinase inhibitors (TKI) offer targeted cancer therapy.
- Selecting patients who will respond to TKI therapy is challenging.
Purpose of the Study:
- To review recent advancements in non-invasive imaging for assessing tumor response to TKI therapy.
- To highlight the shift from invasive biopsies to non-invasive methods for early response detection.
Main Methods:
- Review of recent developments in anatomical, functional, and molecular imaging techniques.
- Exploration of novel targeting peptides for molecular imaging in TKI-treated tumors.
Main Results:
- Non-invasive imaging allows for early detection of tumor response to TKI therapy, sometimes within days.
- Molecular imaging has led to the discovery of new probes targeting TKI-responding tumors.
Conclusions:
- Non-invasive imaging is a powerful tool for monitoring TKI therapy effectiveness.
- Advancements in imaging support the move towards personalized medicine in cancer treatment.
