Related Experiment Video
Updated: Jun 1, 2026
06:00
Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen
Published on: January 26, 2024
Current and nano-diagnostic tools for dengue infection
Alister En Kai Peh1, Yee-Sin Leo, Chee Seng Toh
1Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore.
Frontiers in Bioscience (Scholar Edition)
|May 31, 2011
Summary
Early dengue diagnosis is crucial for controlling epidemics and preventing severe illness. This study reviews current and advanced diagnostic methods, including novel nanosensor technologies for rapid, point-of-care detection.
Area of Science:
- Medical Diagnostics
- Infectious Diseases
- Nanotechnology
Background:
- Dengue fever is a global infectious disease with recurring, potentially fatal epidemics.
- Effective disease control necessitates rapid and specific diagnostic tools for early detection.
- Timely diagnosis prevents complications and aids management during outbreaks.
Purpose of the Study:
- To review current and advanced diagnostic methods for dengue infection.
- To discuss the analytical performance and clinical applicability of these methods.
- To explore emerging technologies for point-of-care dengue diagnostics.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA)
- Reverse transcriptase polymerase chain reaction (RT-PCR)
- Advanced instrumental techniques (QCM, SPR, photonic crystals, EIS)
- Nanosized materials (liposomes, nanowires, nanopores) coupled with detection methods (fluorescence, potentiometry, voltammetry)
Main Results:
- Conventional methods like ELISA and RT-PCR are discussed.
- Instrumental methods show promising diagnostic potential.
- Nanosensor technologies offer innovative approaches for dengue detection.
Conclusions:
- A range of diagnostic methods exist for dengue infection.
- Advanced instrumental and nanosensor-based techniques offer improved sensitivity and speed.
- Future developments aim for inexpensive, point-of-care diagnostics for epidemic situations.
