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Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Related Experiment Video

Updated: Jun 1, 2026

Extracellular Vesicle Tissue Factor Activity Assay
03:53

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Tissue factor signaling: a multi-faceted function in biological processes.

Lisa G van den Hengel1, Henri H Versteeg

  • 1The Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Frontiers in Bioscience (Scholar Edition)
|May 31, 2011
PubMed
Summary

Tissue factor (TF) initiates coagulation but also regulates cell migration and survival. This review explores TF

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Last Updated: Jun 1, 2026

Extracellular Vesicle Tissue Factor Activity Assay
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Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

Published on: September 14, 2021

Area of Science:

  • Cellular biology
  • Molecular signaling
  • Biochemistry

Background:

  • Tissue factor (TF) is traditionally known for its role in initiating blood coagulation.
  • Emerging evidence highlights TF's involvement in diverse cellular processes, including migration and anti-apoptosis.
  • TF-mediated signaling influences gene expression and protein synthesis, altering cellular behavior.

Purpose of the Study:

  • To review the mechanisms of intracellular signaling mediated by Tissue Factor (TF).
  • To elucidate the physiological and pathological consequences of TF signaling.
  • To highlight the role of TF in processes such as angiogenesis, cancer growth, and inflammation.

Main Methods:

  • Literature review focusing on TF-mediated intracellular signaling pathways.
  • Analysis of in vivo studies investigating TF's contribution to pathological processes.
  • Discussion of key molecular events in TF signaling, including FVIIa activity, integrin interaction, and PAR activation.

Main Results:

  • TF signaling regulates gene expression and protein synthesis, impacting cellular functions.
  • Key signaling events involve factor VIIa (FVIIa) proteolytic activity, beta-1 integrin interactions, and protease-activated receptor (PAR) activation.
  • TF signaling significantly contributes to angiogenesis, cancer progression, and inflammatory responses.

Conclusions:

  • TF is a multifunctional protein with critical roles beyond coagulation.
  • Understanding TF-mediated intracellular signaling is crucial for comprehending its pathological roles.
  • Further research into TF post-translational modifications may reveal novel regulatory mechanisms.