SLiMSearch 2.0: biological context for short linear motifs in proteins

Norman E Davey1, Niall J Haslam, Denis C Shields

  • 1Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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