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Updated: Aug 19, 2026

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Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
Published on: July 22, 2011
Lithium counteracts histamine suppression of human T cell mitogenesis
T J Hall1, C Heckel, B N Hudspith
1Merrell Dow Research Institute, Strasbourg, France.
Immunology Letters
|May 1, 1990
Abstract:
Human T cell proliferative responses to concanavalin A (conA) were suppressed by approximately 50% by histamine (100 microM). In contrast, LiCl (1 or 3 mM) potentiated T cell responses by about 50%, but 10 mM LiCl had no significant effect on T cell proliferation. Histamine suppression was not significantly affected by the presence of potentiating concentrations of LiCl, whereas 10 mM LiCl completely abrogated histamine suppression.

