Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Management of congenital lobar emphysema with endobronchial intubation and controlled ventilation.

Anesthesia and analgesia·1998

Same author

An unusual choledochal cyst.

Journal of gastroenterology and hepatology·1998

Same author

The single-copy gene encoding high-mobility-group protein HMG-I/Y from pea contains a single intron and is expressed in all organs.

Plant molecular biology·1998

Same author

Functions of SH2 and SH3 domains.

Current topics in microbiology and immunology·1997

Same author

Growth inhibition of B-cell precursor acute lymphoblastic leukemia cell lines by monocytes: a role for prostaglandin E2.

Leukemia research·1997

Same author

Coronary heart disease in India.

Circulation·1997

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

Neuroprotection in acute ischemic stroke.

A Reza Noorian¹, R Nogueira, R Gupta

¹Department of Neurology, Emory University School of Medicine, Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA, USA.

Journal of Neurosurgical Sciences

|May 31, 2011

Summary

Neuroprotective strategies for acute ischemic stroke aim to improve outcomes by extending treatment windows and protecting the brain post-reperfusion. Clinical trials need better patient selection and linkage to reperfusion for success.

More Related Videos

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

Related Experiment Videos

Last Updated: Jun 1, 2026

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

Area of Science:

Neurology
Cerebrovascular Diseases
Neuroprotection

Background:

Acute ischemic stroke is a leading cause of death and disability globally.
Reperfusion therapies improve outcomes but have limited time windows.
Neuroprotective strategies show promise in preclinical models but have failed in clinical trials.

Purpose of the Study:

To explore the potential of neuroprotective strategies in acute ischemic stroke.
To investigate methods for prolonging therapeutic time windows for reperfusion.
To identify reasons for the clinical failure of previous neuroprotection studies.

Main Methods:

Review of existing literature on acute ischemic stroke pathophysiology and treatment.
Analysis of factors contributing to the success or failure of neuroprotective agents.
Examination of patient selection criteria and timing in clinical trials.

Main Results:

Reperfusion treatments are effective but limited by time constraints.
Neuroprotective agents have not translated successfully to clinical benefit.
Clinical trial failures may stem from poor patient selection and trial design.

Conclusions:

Neuroprotection could extend reperfusion time windows, increasing patient eligibility.
Strategies to protect the brain post-reperfusion may prevent complications like edema and hemorrhage.
Future clinical success requires improved patient selection and integration with reperfusion therapies.