BK virus associated nephropathy in renal transplantation: where do we stand

BK virus is an increasingly identified complication in renal allograft recipients. During the last decade, the use of potent immunosuppressive medications has led to reemergence of this virus. Despite the paucity of randomized trials, we have come a long way in the knowledge of BK virus associated nephropathy. This review highlights the epidemiological, pathogenic, pathological, and clinical aspects of BK virus. It summarizes advances made in prophylaxis and treatment strategies to curtail this virus in an era of modern immunosuppression. The old word of wisdom- prevention is better than cure- might be relevant in context of BK virus prophylaxis with flouroquinolones in years to follow.