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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
Published on: January 12, 2017
Current and emerging bladder cancer urinary biomarkers.
Justin Parker1, Philippe E Spiess
1Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA. jparker1@health.usf.edu
Thescientificworldjournal
|May 31, 2011
Summary
Bladder cancer surveillance relies on invasive cystoscopy. Developing sensitive and specific urinary markers could enable noninvasive diagnosis and reduce procedures for patients with bladder cancer.
Area of Science:
- Urology
- Oncology
- Biomarker Discovery
Background:
- Bladder cancer is a common malignancy with a high risk of recurrence, particularly high-grade disease.
- Current diagnosis and surveillance depend on invasive cystoscopy, which carries risks and discomfort.
- Existing urinary cytology tests have limited sensitivity and specificity for bladder cancer detection.
Purpose of the Study:
- To review currently available urinary bladder cancer markers.
- To discuss new and investigational urinary markers with potential clinical utility.
- To highlight the goal of developing a noninvasive, highly sensitive, and specific urinary marker for bladder cancer.
Main Methods:
- Literature review of existing and emerging urinary bladder cancer biomarkers.
- Analysis of diagnostic performance metrics for various assays.
- Discussion of the clinical implications and future directions for noninvasive bladder cancer detection.
Main Results:
- Several urinary assays are available, but none currently offer definitive high sensitivity and specificity.
- Investigational markers show promise for improved noninvasive bladder cancer detection.
- The development of an ideal urinary marker remains an ongoing objective.
Conclusions:
- Noninvasive urinary markers are crucial for improving bladder cancer diagnosis and surveillance.
- Further research is needed to validate promising investigational markers for clinical use.
- Successful development of a highly sensitive and specific urinary marker would significantly benefit patient care by reducing the need for cystoscopies.
