Jove
Visualize
Contact Us

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The CYB5R3 T117S Missense Variant is Associated with Attenuated Riociguat Efficacy in Sickle Cell Disease.

Blood·2026
Same author

Effect of Opt-Out HIV Testing for Adolescent Patients on a Pediatric Hospital Medicine Service.

Hospital pediatrics·2026
Same author

Azithromycin for Preschoolers with Wheezing in the Emergency Department.

The New England journal of medicine·2026
Same author

Medically Unnecessary Venipuncture in Autism Spectrum Disorder Behavior Assessments.

Pediatric emergency care·2026
Same author

Interventions to Prevent Post-Discharge Mortality among Children in Sub-Saharan Africa: A Systematic Review.

The American journal of tropical medicine and hygiene·2026
Same author

Clinician Assessment for Acute Chest Syndrome in Febrile Children With Sickle Cell Disease Revisited.

American journal of hematology·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 1, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Asthma in sickle cell disease.

Manisha Newaskar1, Karen A Hardy, Claudia R Morris

  • 1Bay Area Pediatric Pulmonary Medical Corporation, Oakland, CA, USA. mnewaskar@mail.cho.org

Thescientificworldjournal
|May 31, 2011
PubMed
Summary

Asthma increases sickle cell disease (SCD) complications and mortality. Underlying hemolysis may cause asthma-like pulmonary issues in SCD patients, necessitating early asthma diagnosis and management.

Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Immunology

Background:

  • Asthma is increasingly linked to severe sickle cell disease (SCD) complications, including pain crises, acute chest syndrome, pulmonary hypertension, stroke, and mortality.
  • Patients with SCD exhibit obstructive pulmonary function and higher airway hyper-responsiveness (AHR) than the general population, suggesting underlying pulmonary disease.
  • Hemolysis in SCD may contribute to asthma-like pulmonary conditions, though exact mechanisms for AHR and lung disease in SCD remain unclear.

Purpose of the Study:

  • To explore the potential link between hemolysis in SCD and the development of asthma-like pulmonary dysfunction.
  • To investigate the pathophysiologic mechanisms contributing to airway hyper-responsiveness and lung disease in SCD patients.
  • To emphasize the importance of early asthma recognition and management in SCD.

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Related Experiment Videos

Last Updated: Jun 1, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Main Methods:

  • Review of existing evidence linking asthma to SCD complications.
  • Analysis of pulmonary function patterns and airway hyper-responsiveness prevalence in SCD patients.
  • Discussion of potential pathophysiologic mechanisms including inflammation and nitric oxide metabolism.

Main Results:

  • Asthma is a significant risk factor for SCD complications and mortality.
  • SCD patients show obstructive lung patterns and increased AHR, potentially due to hemolysis.
  • Inflammation and dysregulated arginine-nitric oxide metabolism are implicated in SCD-related pulmonary dysfunction.

Conclusions:

  • Asthma exacerbates SCD, increasing morbidity and mortality.
  • Hemolysis-driven inflammation and altered nitric oxide metabolism may cause pulmonary dysfunction in SCD.
  • Aggressive asthma management following NIH guidelines is crucial for reducing complications in SCD patients.