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A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects (TEdeff) in Cancers
10:49

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects (TEdeff) in Cancers

Published on: September 26, 2019

CKD-MBD: an endless story

Diego Brancaccio1, Mario Cozzolino

  • 1Renal Unit Simone Martini, Milan, Italy. diego.brancaccio@tiscalinet.it

Journal of Nephrology
|May 31, 2011
PubMed

Insights

Chronic kidney disease (CKD) patients often develop mineral bone disorders (MBD) and cardiovascular issues due to altered calcium-phosphate metabolism. This review updates understanding of CKD-MBD pathogenesis and treatment strategies.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiology

Background:

  • Chronic kidney disease (CKD) affects a large population, causing significant social impact.
  • CKD complications include mineral bone disorders (MBD) and cardiovascular diseases.
  • Early derangements in calcium-phosphate (Ca-P) metabolism, phosphate homeostasis, and reduced calcitriol synthesis are critical in CKD patients.

Purpose of the Study:

  • To review recent contributions to the understanding of CKD-MBD.
  • To update knowledge on the pathogenetic mechanisms of CKD-MBD.
  • To discuss the most appropriate therapeutic approaches for CKD-MBD.

Main Methods:

  • Literature review of recent scientific contributions.
  • Analysis of observational studies on vitamin D receptor activators.
  • Examination of novel mechanisms in secondary hyperparathyroidism.

Main Results:

  • Vitamin D receptor activators may offer cardiovascular and metabolic benefits beyond lowering parathyroid hormone.
  • The treatment of secondary hyperparathyroidism is complex, involving cinacalcet hydrochloride and new pathogenetic insights.

Conclusions:

  • Understanding CKD-MBD pathogenesis is crucial for effective management.
  • Novel therapeutic strategies are emerging for secondary hyperparathyroidism in CKD.
  • Integrated approaches are needed to address the multifaceted complications of CKD.

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