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Updated: Jun 1, 2026

Infinium Assay for Large-scale SNP Genotyping Applications
Published on: November 19, 2013
SNP sets and reading ability: testing confirmation of a 10-SNP set in a population sample
Michelle Luciano1, Grant W Montgomery, Nicholas G Martin
1Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, United Kingdom. michelle.luciano@ed.ac.uk
None:
A set of 10 SNPs associated with reading ability in 7-year-olds was reported based on initial pooled analyses of 100K SNP chip data, with follow-up testing stages using pooling and individual testing. Here we examine this association in an adolescent population sample of Australian twins and siblings (N = 1177) aged 12 to 25 years. One (rs1842129) of the 10 SNPs approached significance (P = .05) but no support was found for the remaining 9 SNPs or the SNP set itself. Results indicate that these SNPs are not associated with reading ability in an Australian population. The results are interpreted as supporting use of much larger SNP sets in common disorders where effects are small.
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