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Related Experiment Video

Updated: Jun 1, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Primary cutaneous CD20-positive T-cell lymphoma.

Blanca Martin¹, Catherine Stefanato, Sean Whittaker

¹Department of Dermatopathology, St John's Institute of Dermatology, St Thomas Hospital, London, UK. blancamartin@hotmail.com

Journal of Cutaneous Pathology

|June 1, 2011

Summary

CD20-positive T-cell lymphoma is rare, especially primary cutaneous types. This study examines two new cases, exploring CD20 expression in T-cells and its potential origins and implications.

Related Experiment Videos

Last Updated: Jun 1, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Area of Science:

Hematology
Oncology
Immunology

Background:

CD20 is a B-cell marker, typically used for B-lineage cell identification.
CD20-positive T-cell lymphomas are infrequent but recognized, with varied clinical and histoimmunochemical profiles.
Primary cutaneous CD20-positive T-cell lymphoma is exceptionally rare, with only eight prior reports.

Observation:

This study presents two new cases of primary cutaneous CD20-positive T-cell lymphoma.
The cases detail clinical, histological, and immunohistochemical features.
CD20 expression has been noted in a subset of normal T-cells, often co-expressing CD8 and g/d.

Findings:

Two theories explain CD20 expression in neoplastic T-cells: origin from a CD20-positive T-cell subset or CD20 as an activation marker.
The specific subset of T-cells expressing CD20 also more frequently expresses CD8 and g/d.

Implications:

Further research is needed to elucidate the prognostic implications of CD20 positivity in T-cell lymphomas.
Therapeutic strategies for CD20-positive T-cell lymphomas require further investigation.