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Updated: Jun 1, 2026
06:39
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
Focal segmental glomerulosclerosis after renal transplantation
Akira Shimizu1, Seiichiro Higo, Emiko Fujita
1Department of Pathology (Analytic Human Pathology), Nippon Medical School, Tokyo, Japan. ashimizu@nms.ac.jp
Clinical Transplantation
|June 1, 2011
Summary
Focal segmental glomerulosclerosis (FSGS) is a kidney disease causing proteinuria and potentially end-stage renal disease. This review discusses FSGS recurrence and de novo cases after kidney transplantation.
Area of Science:
- Nephrology
- Pathology
- Transplantation Medicine
Background:
- Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage renal disease (ESRD).
- FSGS recurrence post-kidney transplantation affects approximately 30% of patients.
- De novo FSGS can also develop in allografts, contributing to graft dysfunction.
Purpose of the Study:
- To review the pathology of recurrent and de novo FSGS after kidney transplantation.
- To highlight risk factors associated with FSGS recurrence.
- To discuss mechanisms contributing to de novo FSGS in transplanted kidneys.
Main Methods:
- Review of existing literature on FSGS pathology, recurrence, and de novo development.
- Analysis of pathological features and risk factors based on clinical and research data.
- Discussion of diagnostic criteria using the Columbia classification system.
Main Results:
- Identified key risk factors for recurrent FSGS, including childhood onset, rapid progression to ESRD, and specific histological patterns.
- Described pathological findings in recurrent FSGS, emphasizing podocyte injury.
- Outlined causes of de novo FSGS, such as hyperfiltration injury and immunosuppressive drug toxicity.
Conclusions:
- FSGS is a podocyte-centric disease with significant implications for kidney transplant outcomes.
- Understanding the pathology of recurrent and de novo FSGS is crucial for patient management and improving graft survival.
- Further research into the pathogenesis of FSGS is needed to develop targeted therapies.
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