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Updated: Jun 1, 2026
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid autoimmunity and recurrent miscarriage.
Carlo Ticconi1, Emma Giuliani, Manuela Veglia
1Section of Gynecology and Obstetrics, Department of Surgical Sciences, University Tor Vergata, Rome, Italy. ticconi@med.uniroma2.it
Summary
Antithyroid autoantibodies (ATA) are more common in women with recurrent miscarriage (RM). These antibodies, especially against thyroglobulin (TG-Ab), may indicate broader maternal immune issues contributing to RM, regardless of thyroid function.
Area of Science:
- Immunology
- Reproductive Medicine
- Endocrinology
Background:
- Recurrent miscarriage (RM) affects a significant number of women.
- The role of maternal autoimmunity in RM is an area of ongoing research.
- Antithyroid autoantibodies (ATA) are implicated in various autoimmune conditions.
Purpose of the Study:
- To determine the association between ATA and recurrent miscarriage.
- To investigate specific ATA (TG-Ab, TPO-Ab, TSHr-Ab) in women with RM.
- To explore the potential link between ATA and general maternal immune system abnormalities.
Main Methods:
- A case-control study involving 160 women with RM and 100 healthy controls.
- Serum samples were analyzed for TG-Ab, TPO-Ab, and TSHr-Ab using chemiluminescence or radioimmunoassay.
- Participants' thyroid hormone status was assessed, with most being euthyroid.
Main Results:
- ATA were detected in 28.75% of women with RM versus 13% in controls (P < 0.05).
- Frequencies of TG-Ab and TPO-Ab were significantly higher in the RM group.
- A high proportion (91.3%) of ATA-positive RM patients also had other autoantibodies.
Conclusions:
- ATA, particularly TG-Ab, are significantly associated with recurrent miscarriage.
- ATA may reflect a more generalized maternal immune dysregulation contributing to RM.
- The association between ATA and RM appears independent of thyroid hormone levels.
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