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Updated: Jun 1, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid autoimmunity and recurrent miscarriage
Carlo Ticconi1, Emma Giuliani, Manuela Veglia
1Section of Gynecology and Obstetrics, Department of Surgical Sciences, University Tor Vergata, Rome, Italy. ticconi@med.uniroma2.it
Problem:
To investigate the role of antithyroid autoantibodies (ATA) in recurrent miscarriage (RM).
Methods:
In this case-control study, a total of 160 women with RM and 100 healthy women were investigated for the presence of serum ATA directed against thyreoglobulin (TG-Ab), thyroid peroxidase (TPO-Ab) and TSH receptor (TSHr-Ab), which were determined by either chemiluminescence or radioimmunoassay.
Results:
Antithyroid autoantibodies were detected in 46 (28.75%) women with RM and in 13 (13%) women of the control group (P < 0.05). The frequencies for TG-Ab and TPO-Ab were higher in RM than in control women. Among the women of RM group, 91.3% of ATA+ women were positive also for other autoantibodies. The majority of study women were euthyroid.
Conclusions:
Antithyroid autoantibodies, particularly TG-Ab, are associated with RM and could be an expression of a more general maternal immune system abnormality leading to RM. ATA could have a role in RM irrespective of thyroid hormone status.
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