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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
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[Metabolic syndrome is an independent risk factor for cardiovascular disease events in patients with ischemic stroke]

Chuan Liu1, Ming Feng, Xiang-hua Fang

  • 1Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|June 1, 2011
PubMed

Insights

Metabolic syndrome (MS) significantly increases the risk of cardiovascular disease (CVD) events in patients who have had an ischemic stroke. The risk of CVD events rises with an increasing number of MS components, indicating a dose-response relationship.

Area of Science:

  • Cardiology
  • Neurology
  • Endocrinology

Background:

  • Metabolic syndrome (MS) is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
  • Ischemic stroke is a major cause of long-term disability and death worldwide.

Purpose of the Study:

  • To investigate the association between metabolic syndrome (MS) and the risk of subsequent cardiovascular disease (CVD) events in patients with a history of ischemic stroke.

Main Methods:

  • A cohort of 1087 patients with ischemic stroke was followed for an average of 3.5 years.
  • Metabolic syndrome was diagnosed using the CDS criteria.
  • Proportional hazard models were employed to analyze the risk of CVD events.

Main Results:

  • The prevalence of MS was 40.4% at baseline.
  • Patients with MS had a 44% higher risk of CVD events compared to those without MS (HR: 1.44).
  • A dose-response relationship was observed, with 3 or more MS components increasing CVD event risk by 69% (HR: 1.69).

Conclusions:

  • Metabolic syndrome is an independent predictor of increased cardiovascular disease event risk in ischemic stroke survivors.
  • A greater number of metabolic syndrome components correlates with a higher risk of cardiovascular events, suggesting a significant dose-response effect.
Abstract

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