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Related Concept Videos

Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
Bioreactor Controls-II01:18

Bioreactor Controls-II

In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...
Designing Growth Media for Bioreactors01:30

Designing Growth Media for Bioreactors

Growth media provide essential nutrients that support cell growth and metabolism, thereby enhancing the yield of valuable products such as enzymes, antibiotics, and biomass. Designing an effective growth medium involves balancing all components to prevent nutrient limitations or toxic excesses, both of which can impair growth and reduce product yields.Composition of a Typical Growth MediumA typical growth medium contains carbon and nitrogen sources, salts, vitamins, trace elements, and...
Bioreactor Controls-I01:28

Bioreactor Controls-I

Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...
Upstream Processing01:27

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...

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Updated: Jun 1, 2026

Hydrogen Production and Utilization in a Membrane Reactor
10:00

Hydrogen Production and Utilization in a Membrane Reactor

Published on: March 10, 2023

Bioreactor and process design for biohydrogen production.

Kuan-Yeow Show1, Duu-Jong Lee, Jo-Shu Chang

  • 1Department of Environmental Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Jalan University, Bandar Barat, 31900 Kampar, Perak, Malaysia.

Bioresource Technology
|June 1, 2011
PubMed
Summary

Biohydrogen offers a clean, renewable energy alternative to fossil fuels. This review covers advances in bioreactor and bioprocess design for efficient biohydrogen production.

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Published on: December 25, 2015

Area of Science:

  • Renewable Energy
  • Biotechnology
  • Chemical Engineering

Background:

  • Biohydrogen is a promising clean energy carrier with high energy content.
  • Current hydrogen production relies heavily on fossil fuels.
  • Biohydrogen offers a renewable biofuel alternative.

Purpose of the Study:

  • To review advances in bioreactor and bioprocess design for biohydrogen production.
  • To discuss the state-of-the-art in biohydrogen production technologies.
  • To outline challenges and prospects in the field.

Main Methods:

  • Literature review of laboratory- and pilot-scale biohydrogen production systems.
  • Analysis of different production pathways and influencing factors.
  • Examination of bioreactor configurations and operational strategies.

Main Results:

  • Various bioreactor and bioprocess designs have shown promising potential for biohydrogen production.
  • Key factors affecting biohydrogen yield and efficiency have been identified.
  • Current state-of-the-art production pathways and technologies are discussed.

Conclusions:

  • Biohydrogen production is a developing field with significant potential as a clean energy source.
  • Further advancements in bioreactor and bioprocess design are crucial for commercial viability.
  • Addressing current challenges will pave the way for future prospects in renewable biohydrogen.