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Published on: June 26, 2020
Severe acute hepatitis B treated with entecavir
Giuseppe Vittorio Luigi De Socio1, Alessio Sgrelli, Andrea Tosti
1Department of Infectious Diseases "Santa Maria della Misericordia" Hospital, University of Perugia, Perugia Italy.
Abstract:
Hepatitis B virus (HBV) infection constitutes a serious global health problem. Nowadays there are divergent data regarding the use of antiviral drugs to treat acute hepatitis B. We present here a case of a 62-year-old man affected by severe acute hepatitis B with progressive worsening of clinical and hepatic function. The patient was treated with entecavir without critical side effects. We observed rapid clinical and laboratory improvements and the disappearance of hepatitis B surface antigen (HBsAg). The treatment with entecavir was protracted until 17(th) week when the antibody anti-HBs appeared. Entecavir should be carefully considered for the treatment of severe acute hepatitis B cases.
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