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Published on: June 26, 2020
Severe acute hepatitis B treated with entecavir.
Giuseppe Vittorio Luigi De Socio1, Alessio Sgrelli, Andrea Tosti
1Department of Infectious Diseases "Santa Maria della Misericordia" Hospital, University of Perugia, Perugia Italy.
Summary
Entecavir effectively treated severe acute hepatitis B in a 62-year-old man, leading to rapid recovery and HBsAg clearance. This antiviral offers a promising option for managing severe acute hepatitis B cases.
Area of Science:
- Hepatology
- Virology
- Pharmacology
Background:
- Hepatitis B virus (HBV) infection is a significant global health concern.
- Current data on antiviral treatment for acute hepatitis B is inconsistent.
- Severe acute hepatitis B can lead to critical clinical and hepatic function deterioration.
Observation:
- A 62-year-old male presented with severe acute hepatitis B and worsening liver function.
- The patient received entecavir treatment.
- No critical side effects were observed during entecavir therapy.
Findings:
- Rapid clinical and laboratory improvements were noted post-entecavir treatment.
- Hepatitis B surface antigen (HBsAg) disappeared during the treatment course.
- Anti-HBs antibodies appeared by the 17th week of entecavir therapy.
Implications:
- Entecavir demonstrates potential efficacy in managing severe acute hepatitis B.
- This case suggests entecavir is a viable treatment option for severe acute HBV.
- Further investigation into entecavir for acute hepatitis B is warranted.
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