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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...

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Related Experiment Video

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Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
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Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

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Amyloid-associated nucleic acid hybridisation.

Sebastian Braun1, Christine Humphreys, Elizabeth Fraser

  • 1School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom.

Plos One
|June 1, 2011
PubMed
Summary
This summary is machine-generated.

Nucleic acids and basic peptides form novel amyloid-nucleic acid (ANA) fibers. These ANA fibers enhance amyloid formation and nucleic acid hybridization, with implications for disease and early evolution.

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Rapid Generation of Amyloid from Native Proteins In vitro
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Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Nucleic acids are implicated in amyloid formation in neurodegenerative diseases.
  • The role of nucleic acid secondary structure in modulating amyloid properties is not well understood.

Purpose of the Study:

  • To investigate the interactions between nucleic acids and amyloid-forming peptides.
  • To elucidate the structural and functional consequences of these interactions.

Main Methods:

  • Utilized a simplified system of short basic peptides.
  • Employed biophysical techniques: X-ray fiber diffraction, circular dichroism spectroscopy, electron microscopy, and time-resolved Förster resonance energy transfer (TR-FRET).

Main Results:

  • Nucleic acids concentrate and enhance amyloid formation from peptides.
  • Amyloid components bind nucleic acids, promoting hybridization below solution K(d).
  • Formation of distinct amyloid-nucleic acid (ANA) fibers with unique properties.

Conclusions:

  • Self-reinforcing interactions between peptides and nucleic acids create ANA fibers.
  • ANA fibers have implications for understanding diseases, biomaterial engineering, and the origins of life.
  • These structures may represent early entities subject to Darwinian evolution.