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Association between type 2 diabetes and CDKN2A/B: a meta-analysis study

Xiao Yun Bao1, Cui Xie, Mao Sheng Yang

  • 1Laboratory of Disorder Genes and Department of Pharmacology, College of Pharmacy, Chongqing Medical University, P.O. 380, 1 Yi Xue Yuan Road, Chongqing 400016, People's Republic of China.

Molecular Biology Reports
|June 1, 2011
PubMed

Insights

The rs10811661 T allele in the CDKN2A/B gene is linked to an increased risk of type 2 diabetes (T2D). This meta-analysis confirms the association, particularly in European and Asian populations, warranting further investigation.

Area of Science:

  • Genetics
  • Endocrinology
  • Metabolic Diseases

Background:

  • The Cyclin-dependent kinase inhibitor-2A/B (CDKN2A/B) gene is implicated in type 2 diabetes (T2D) due to its role in pancreatic beta-cell function.
  • Previous studies on the association between CDKN2A/B and T2D have yielded inconsistent results.

Purpose of the Study:

  • To clarify the association between T2D and specific single nucleotide polymorphisms (SNPs) in the CDKN2A/B gene.
  • To conduct a meta-analysis on the prevalence of alleles and genotypes for rs10811661 and rs564398 in CDKN2A/B.

Main Methods:

  • Systematic review of PubMed, EMBASE, and Medline databases for studies published between January 2006 and November 2010.
  • Meta-analysis of 16 selected studies, comprising 24,407 T2D cases and 33,937 controls.
  • Statistical analysis of allele and genotype frequencies for rs10811661 and rs564398 within the CDKN2A/B gene.

Main Results:

  • The rs10811661 T allele (OR 1.28) and TT genotype (OR 1.32) in CDKN2A/B were significantly associated with an increased risk of T2D.
  • No significant association was found for rs564398 in CDKN2A/B with T2D.
  • The association of the rs10811661 T allele with T2D was consistent across Asian and European ethnic groups.

Conclusions:

  • The rs10811661 variant in the CDKN2A/B gene is a risk factor for type 2 diabetes.
  • Further large-scale studies involving diverse ethnicities are needed to validate these findings.

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