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Updated: Jun 1, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Human cytomegalovirus latency-associated protein LUNA is expressed during HCMV infections in vivo
Mariana G Bego1, Lisa R Keyes, Jarek Maciejewski
1Institut de recherches cliniques de Montréal, 110, avenue des Pins Ouest, Montreal, QC, H2W 1R7, Canada.
Abstract:
Human cytomegalovirus (HCMV) latency is poorly understood. We previously described a novel HCMV latency-associated transcript, UL81-82ast, coding for a protein designated LUNA (latency unique natural antigen). The aim of this study was to confirm the presence of LUNA in HCMV-seropositive donors. Standard co-immunoprecipitation and ELISA assays were used to detect antibodies against the LUNA protein in the sera of HCMV-seropositive donors. Specific antibodies against LUNA were detected in all HCMV-seropositive donors but in none of the seronegative donors. These data confirm that LUNA is expressed during in vivo infections and is capable of eliciting an immune response.
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