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Diagnostic and management of pediatric brain stem abscess, a case-based update
Houssine Ghannane1, Mehdi Laghmari, Khalid Aniba
1Department of Neurosurgery, UHC Mohammed VI, Faculty of Medicine, Cadi Ayyad University, Marrakesh, Morocco.
Insights
Pediatric brain stem abscesses are rare but require high clinical suspicion for optimal outcomes. Microsurgical or stereotactic aspiration are effective treatments, leading to good recovery in pediatric cases.
Area of Science:
- Pediatric Neurology
- Neurosurgery
- Infectious Diseases
Background:
- Pediatric brain stem abscesses are uncommon neurological emergencies.
- Early diagnosis is often delayed despite significant neurological deficits.
Observation:
- A 2.5-year-old girl with a delayed diagnosis of brain stem abscess presented with hemiparesis, cranial nerve palsies, and respiratory issues.
- Magnetic resonance imaging confirmed a pontine abscess, necessitating microsurgical aspiration.
- The patient achieved full neurological recovery post-surgery with lesion regression over four months.
Findings:
- The mean age for pediatric brain stem abscess is 8.1 years, with no gender predilection.
- Common symptoms include increased intracranial pressure, motor deficits, and cranial nerve palsies.
- While mortality has decreased since the 1980s, significant morbidity, particularly affecting motor function, persists.
Implications:
- A high index of clinical suspicion is crucial for improving functional outcomes in pediatric brain stem abscess.
- Stereotactic-guided or microsurgical aspiration remain viable and effective therapeutic strategies.
- This case highlights the importance of timely diagnosis and management of rare pediatric central nervous system infections.
Purpose:
Authors report their experience of a pediatric brain stem abscess with a literature review.
Methods:
A 2.5-year-old girl first displayed bacterial otitis 3 months before admission. Diagnosis of brain stem abscess was delayed, despite plethoric neurological signs. She complained of right hemiparesis, headache, squint, dysphagia, and false way inhalation pneumopathy. Brain magnetic resonance imaging revealed presence of an abscess in the pons, prompting for a microsurgical pus aspiration. Postoperative course was regular with a total neurological recovery. Clinical and radiological screening showed progressive regression of the pontine lesion after 4 months, despite persistence of a mild contrast enhancement. Present case is the 18th pediatric brain stem abscess reported in literature.
Results:
Mean age of occurrence is 8.1 ± 4 years (range 0.75-16) without gender predominance. High morbidity is typical and essentially involves motor functions. The most common clinical signs are raised intracranial pressure, motor limbs deficit, and cranial nerve palsies. Fever was found in 10 out of 18 cases (56%). Three patients received conservative medical treatment. Three patients underwent stereotactic aspiration and 12 others underwent microsurgical aspiration or excision. No mortality was reported since the eighties. However, morbidity is still high.
Conclusion:
High clinical index of suspicion is necessary to improve functional outcome. Stereotactic-guided or microsurgical aspiration are still good therapeutic options. The rarity of pediatric brain stem abscesses and the need of optimal management make this case-based update very peculiar.
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